Newsroom, your daily review

Keep up with the latest in the tableting community!


Feature article

MySTYL'One

May 18, 2022

Chat around a coffee: Air entrapment during tablet compression

MySTYL'One users exclusive!

We're inviting you to chat with Calvin Sun Changquan and Gerrit Vreeman from University of Minnesota on Air entrapment during tablet compression - Diagnosis, impact on tableting performance, and mitigation strategies on Wednesday, May 24th @4:30pm Paris time.

Calvin Sun and Gerrit have published in the International Journal of Pharmaceutics and have studied the role of air entrapment during tablet compression using a compaction simulator. The impact of air entrapment is pressure dependent and deaeration (by applying a pre-compression step) can be an effective mitigation strategy. Though, the degree of improvement depends on the level of pressure applied during pre-compression.

 After a short presentation of their paper and results, you can engage in the discussion, ask questions and exchange on the results! 

Don't forget your coffee, tea, juice, water...whathever suits!

This online chat is only open to members of MySTYL'One.

#Upscaling #online chat #paper #chat around coffee #lubricant sensitivity #lubrication

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Press review

Korsch.com

May 18, 2022

The critical role of product flow and die filling


This article discusses essential factors for successful tableting on product flow and consistent die filling. For successful tablet production, many process steps must be harmonized with each other.

Click here for full article

#tableting process #die filling #flowability

Got questions? Ask your peers!

Feature article

MySTYL'One

May 16, 2022

Webinar: "Fundamental Investigations on bilayer tablets"

New MySTYL'One webinar


June  28th, 3 pm (Paris Time)

"Fundamental investigations on bilayer tablets - Effects of process parameters and geometry on interfacial strength"

#multilayer #tablet #interfacial adhesion #delamination #tablet geometry

Call for papers

Webmaster

May 11, 2022

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Help us feed the Community library, by sending us your papers, posters or news on tableting.

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Announcement

MySTYL'One

May 24, 2022

Impact of Amylose-Amylopectin Ratio of Starches on the Mechanical Strength and Stability of Acetylsalicylic Acid Tablets


The present work details how moisture sorption properties of the starches with different amylose-amylopectin ratio impacted tablet properties including drug stability. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Compression Profiles of a Directly Compressible Starch using Compaction Simulation and High-Speed Tablet Press
  • Insights into the Moisture Scavenging Properties of Different Types of Starch in Tablets Containing a Moisture-Sensitive Drug
  • Starch-based...

The present work details how moisture sorption properties of the starches with different amylose-amylopectin ratio impacted tablet properties including drug stability. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Compression Profiles of a Directly Compressible Starch using Compaction Simulation and High-Speed Tablet Press
  • Insights into the Moisture Scavenging Properties of Different Types of Starch in Tablets Containing a Moisture-Sensitive Drug
  • Starch-based controlled release matrix tablets: Impact of the type of starch

#stability #tableting #moisture #Amylose #STYLOne #Amylopectin

Announcement

MySTYL'One

May 16, 2022

Use of jump-tests for the characterization of the viscoplastic behavior of pharmaceutical powders during compaction


The present work details viscoplasticity, especially by choosing products that are known to present little viscoelasticity. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Characterization of the viscoelasticity of pharmaceutical tablets using impulse excitation technique
  • Tablet formulation development focusing on the functional behaviour of water uptake and swelling
  • Characterization and modeling of the viscoelasticity of pharmaceutical tablets

#viscoplasticity #Mechanical behavior #Tablet #speed #strain rate sensitivity #Compaction

Announcement

MySTYL'One

May 9, 2022

Prediction of the impact of lubrication on tablet compactibility


The present work details a model based on the Ryshkewitch-Duckworth equation that can estimate the compactibility profiles of lubricated formulations. Available model showing extended quantitative predictive accuracy for the influence of lubricant concentration on the mechanical strength of tablets. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Effect of binder type and lubrication method on the binder efficacy for direct compression
  • Evaluation of an externa...

The present work details a model based on the Ryshkewitch-Duckworth equation that can estimate the compactibility profiles of lubricated formulations. Available model showing extended quantitative predictive accuracy for the influence of lubricant concentration on the mechanical strength of tablets. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Effect of binder type and lubrication method on the binder efficacy for direct compression
  • Evaluation of an external lubrication system implemented in a compaction simulator
  • External lubrication system on the Styl’One Evolution

#tableting #Modeling #Multi-component compaction #Mechanical strength #STYLOne #lubrication

Announcement

MySTYL'One

May 2, 2022

Tablet Disintegration and Dispersion under In Vivo-like Hydrodynamic Conditions


The present work details an in-depth understanding of the functional behaviour of the tablet material, composition and structural properties under in vivo-like hydrodynamic forces regarding disintegration and the temporal progress of dispersion. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis Bullosa
  • Tablet formulation development focusing on the functional behaviour of water uptake and swelling
  • Fate of Tableted Freeze-Dried siRNA Lipoplexes in Gastrointestinal Environment

#Tablet disintegration #disintegrants #tablet performance #pharmaceutical polymers #tomographic imaging #hydrodynamics #in vivo conditions

Announcement

MySTYL'One

April 28, 2022

Predictive modelling of powder compaction for binary mixtures using the finite element method


The present work details powder compaction simulations, using the finite element method (FEM) in combination with the density-dependent Drucker-Prager Cap model, which can be used to aid the design process of pharmaceutical tablets. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Breaking patterns of press-coated tablets during the diametral compression test: Influence of the product, geometry and process parameters
  • Novel ultrasonic in-die measurements during powder compression at production relevant speed
  • Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces

#formulation #Predictive modelling #mechanical properties #Mixing model #Powder compaction #STYLOne #Drucker-Prager Cap model

Announcement

MySTYL'One

April 26, 2022

System model driven selection of robust tablet manufacturing processes based on drug loading and formulation physical attributes


The present work in mechanistic process modeling presents an opportunity to reduce experimental burden, enabling relationships between process parameters and product attributes to be mapped out using in-silico experiments. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Investigating key properties of model excipients and binary powder blends using ultrasonic in-die measurements on a compaction simulator 
  • Impact of Incorporated Drugs on Material Properties of Amorphous Solid Dispersions
  • Systematic approach to elucidate compaction behavior of acyclovir using a compaction simulator

#Design space #Pharmaceutical process #STYLOne #System model #Formulation design

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