Newsroom, your daily review

Keep up with the latest in the tableting community!


Feature article

MySTYL'One

Jan. 31, 2023

Webinar: "Assessing temperature influence on tablet quality attributes"

February  28th, 3pm (Paris Time)

"Assessing temperature influence on tablet quality attributes - Using a temperature-controlled die on the STYL’One Evo compaction simulator"

#STYL'One evo #compaction simulator #sticking #picking #temperature influence #webinar

Publish with us!

Interesting news to share with the community?
Carried a new study out?
This newsfeed is yours, do not hesitate!

Announcement

MySTYL'One

Jan. 30, 2023

Dosage Form Design and Patient Compliance: Exploring Orally Disintegrating Tablets as a Patient-Centric Solution


MySTYL'One user exclusive!

This new bulletin available details a study on the needs of different patient groups, identifies frequent issues leading to non-compliance, looks at the role of orally disintegrating tablets (ODTs) in helping improve patient compliance and provides examples of improving the delivery profile of the drug.

#bulletin #oral solid dosage forms #disintegration tablets

Got questions? Ask your peers!

Feature article

Caleva

Jan. 26, 2023

An introduction to Spheronization (or Marumerization)

Spheronization (or Marumerization) is the process where extrudates (the output from an extruder) are shaped into small rounded or spherical granules. In practice these usually vary in size from 0.4 to about 3.0 mm. The use of these spheroids can be relevant for a wide variety of industries.

#Mixer #coater #lab insturment #granulation #R&D #caleva #extruder #spheronization

Announcement

MySTYL'One

Jan. 26, 2023

Usage of compaction simulators for the powder compression characterization – advantages and limitations


In this paper you will find an overview and examples of the different advantages provided by the instrumentation of compaction simulators, including certain limitations in their exploitation.The paper is available in the PAPERS section.

Find others papers here and learn about

  • Scaling Tableting Processes from Compaction Simulator to Rotary Presses—Mind the Sub-Processes
  • Impact of material properties, process parameters and roll compactor design on roll compaction
  • Precision materials characterizati...

In this paper you will find an overview and examples of the different advantages provided by the instrumentation of compaction simulators, including certain limitations in their exploitation.The paper is available in the PAPERS section.

Find others papers here and learn about

  • Scaling Tableting Processes from Compaction Simulator to Rotary Presses—Mind the Sub-Processes
  • Impact of material properties, process parameters and roll compactor design on roll compaction
  • Precision materials characterization and process modeling

#characterization #advantages #limitations #compaction simulator #powder

Announcement

MySTYL'One

Jan. 26, 2023

Surface Characterization as a Tool for Identifying the Factors Affecting the Dissolution Rate of Amorphous Solid Dispersion Tablets


In this paper you will find a study explaining the interplay between the surface properties and the dissolution rate of ASD tablets. The paper is available in the PAPERS section.

Find others papers here and learn about

  • Understanding the Multidimensional Effects of Polymorphism, Particle Size and Processing for D-Mannitol Powders
  • Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter
  • Fate of Tableted Freeze-Dried siRNA Lipoplexes in Gastrointestinal Environment

#contact angle #STYL'One #Wettability #surface free energy #dissolution rate

Announcement

MySTYL'One

Jan. 19, 2023

Evaluation of alternative methods to derive particle density from compression data


In this paper you will find a study on the methods by Sun and Krumme wich have been investigated in detail regarding their robustness against variations in tableting settings.The paper is available in the PAPERS section.

Find others papers here and learn about

  • Effect of Die Taper and Precompression on Air Entrapment during Tablet Compression
  • Air Entrapment during Tablet Compression – Diagnosis and Impact on Tableting Performance Assessed with a Compaction Simulator
  • Understanding the Multidimensio...

In this paper you will find a study on the methods by Sun and Krumme wich have been investigated in detail regarding their robustness against variations in tableting settings.The paper is available in the PAPERS section.

Find others papers here and learn about

  • Effect of Die Taper and Precompression on Air Entrapment during Tablet Compression
  • Air Entrapment during Tablet Compression – Diagnosis and Impact on Tableting Performance Assessed with a Compaction Simulator
  • Understanding the Multidimensional Effects of Polymorphism, Particle Size and Processing for D-Mannitol Powders

#contact angle #STYL'One #Wettability #surface free energy #dissolution rate

Announcement

MySTYL'One

Jan. 19, 2023

Compressibility analysis as robust in-die compression analysis for describing tableting behaviour


In this paper you will find an investigation on the compressibility constant as an in-die method and has been compared with the Heckel analysis for describing the compressibility of materials during tableting. The paper is available in the PAPERS section.

Find others papers here and learn about

  • Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter
  • Process Modeling and Simulation of Tableting—An Agent-Based Simulation Methodology for Direct Compression
  • Immediate-Re...

In this paper you will find an investigation on the compressibility constant as an in-die method and has been compared with the Heckel analysis for describing the compressibility of materials during tableting. The paper is available in the PAPERS section.

Find others papers here and learn about

  • Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter
  • Process Modeling and Simulation of Tableting—An Agent-Based Simulation Methodology for Direct Compression
  • Immediate-Release Formulations Produced via Twin-Screw Melt Granulation: Systematic Evaluation of the Addition of Disintegrants

#direct compression #compression analysis #sensitivity analysis #compressibility constant #heckel #STYLOne

Feature article

Medelpharm

Jan. 18, 2023

Tableting Rheology and Quality by Design

MySTYL'One members exclusive!

Quality by Design (QbD) in tablet development

can be challenging, due to the multiple competing technological aims, such as flow, compactability, lubrication and drug release. Tablets are complex and, whether due to ignorance or indeterminacy, uncertainty also makes it difficult to develop tablets robust enough to cope with scale-up and Production. Speed sensitivity of the compression mix can come as an unwelcome surprise to those who did not know that tablets have...

MySTYL'One members exclusive!

Quality by Design (QbD) in tablet development

can be challenging, due to the multiple competing technological aims, such as flow, compactability, lubrication and drug release. Tablets are complex and, whether due to ignorance or indeterminacy, uncertainty also makes it difficult to develop tablets robust enough to cope with scale-up and Production. Speed sensitivity of the compression mix can come as an unwelcome surprise to those who did not know that tablets have speed limits! Speed sensitivity may also be called strain rate sensitivity. The penalty for exceeding the speed limit is capping, making tablet production impossible. During development capping/lamination is unacceptable for further progression.

#viscoelasticity #tablet development #scale-up #Quality by Design #capping

Video

Alix Software

Jan. 16, 2023

STYL'One Tutorial - How to mount a specific shape tooling on a STYL'One Nano ?

MySTYL'One members exclusive!

Here is your Tutorial session for a better understanding of new features on Alix Software.

#tooling #software #alix #tutorial #STYL'One Nano

Feature article

Pharmaceutical Manufacturer

Jan. 12, 2023

Customised excipient blends for capsule to tablet formulations

Dr. Sandeep Kumar, Formulation Development manager, Colorcon, sheds light on how selecting an excipient in early formulation development is critical to developing a robust scalable SOD formulation and can help the transition from capsule to tablet formulations.

#R&D #STYL'One evo #MEDELPHARM #containment

Page 1 of 11

Publish with us!