MySTYL'One
May 18, 2022
MySTYL'One users exclusive!
We're inviting you to chat with Calvin Sun Changquan and Gerrit Vreeman from University of Minnesota on Air entrapment during tablet compression - Diagnosis, impact on tableting performance, and mitigation strategies on Wednesday, May 24th @4:30pm Paris time.
Calvin Sun and Gerrit have published in the International Journal of Pharmaceutics and have studied the role of air entrapment during tablet compression using a compaction simulator. The impact of air entrapment is pressure dependent and deaeration (by applying a pre-compression step) can be an effective mitigation strategy. Though, the degree of improvement depends on the level of pressure applied during pre-compression.
After a short presentation of their paper and results, you can engage in the discussion, ask questions and exchange on the results!
Don't forget your coffee, tea, juice, water...whathever suits!
This online chat is only open to members of MySTYL'One.
#Upscaling #online chat #paper #chat around coffee #lubricant sensitivity #lubrication
Interesting news to share with the community?
Carried a new study out?
This newsfeed is yours, do not hesitate!
Korsch.com
May 18, 2022
This article discusses essential factors for successful tableting on product flow and consistent die filling. For successful tablet production, many process steps must be harmonized with each other.
MySTYL'One
May 16, 2022
New MySTYL'One webinar
June 28th, 3 pm (Paris Time)
"Fundamental investigations on bilayer tablets - Effects of process parameters and geometry on interfacial strength"
#multilayer #tablet #interfacial adhesion #delamination #tablet geometry
Webmaster
May 11, 2022
Help us feed the Community library, by sending us your papers, posters or news on tableting.
MySTYL'One
May 24, 2022
The present work details how moisture sorption properties of the starches with different amylose-amylopectin ratio impacted tablet properties including drug stability. Full paper available in the PAPERS section.
Find others papers here and learn about
The present work details how moisture sorption properties of the starches with different amylose-amylopectin ratio impacted tablet properties including drug stability. Full paper available in the PAPERS section.
Find others papers here and learn about
#stability #tableting #moisture #Amylose #STYLOne #Amylopectin
MySTYL'One
May 16, 2022
The present work details viscoplasticity, especially by choosing products that are known to present little viscoelasticity. Full paper available in the PAPERS section.
Find others papers here and learn about
#viscoplasticity #Mechanical behavior #Tablet #speed #strain rate sensitivity #Compaction
MySTYL'One
May 9, 2022
The present work details a model based on the Ryshkewitch-Duckworth equation that can estimate the compactibility profiles of lubricated formulations. Available model showing extended quantitative predictive accuracy for the influence of lubricant concentration on the mechanical strength of tablets. Full paper available in the PAPERS section.
Find others papers here and learn about
The present work details a model based on the Ryshkewitch-Duckworth equation that can estimate the compactibility profiles of lubricated formulations. Available model showing extended quantitative predictive accuracy for the influence of lubricant concentration on the mechanical strength of tablets. Full paper available in the PAPERS section.
Find others papers here and learn about
#tableting #Modeling #Multi-component compaction #Mechanical strength #STYLOne #lubrication
MySTYL'One
May 2, 2022
The present work details an in-depth understanding of the functional behaviour of the tablet material, composition and structural properties under in vivo-like hydrodynamic forces regarding disintegration and the temporal progress of dispersion. Full paper available in the PAPERS section.
Find others papers here and learn about
#Tablet disintegration #disintegrants #tablet performance #pharmaceutical polymers #tomographic imaging #hydrodynamics #in vivo conditions
MySTYL'One
April 28, 2022
The present work details powder compaction simulations, using the finite element method (FEM) in combination with the density-dependent Drucker-Prager Cap model, which can be used to aid the design process of pharmaceutical tablets. Full paper available in the PAPERS section.
Find others papers here and learn about
#formulation #Predictive modelling #mechanical properties #Mixing model #Powder compaction #STYLOne #Drucker-Prager Cap model
MySTYL'One
April 26, 2022
The present work in mechanistic process modeling presents an opportunity to reduce experimental burden, enabling relationships between process parameters and product attributes to be mapped out using in-silico experiments. Full paper available in the PAPERS section.
Find others papers here and learn about
#Design space #Pharmaceutical process #STYLOne #System model #Formulation design