The SeDeM diagram expert system (DES) determines the suitability of excipients and active ingredients for Direct Compression and the ratio of API to excipient is calculated. The DC is most suitable as it saves time and makes process easy, but these technique excipients compensate for their poor flow. Thus, a new system was required to help reduce number of experiments and time for making an optimized direct compression tablet. 

This review mainly focuses on various dosage forms like Solid, Semisolid, Liquisolid, and Solidified liquid dosage forms. These techniques mainly characterize all substances using 12 parameters, resulting 12-sided regular polygon.

This new paper is available here on MySTYL’One. 

New paper from Ghent university. 

External lubrication is a highly valuable alternative lubrication method as it minimizes the negative impact on tablet properties encountered when using internal lubrication. In current study, experiments were performed with automated external lubrication systems implemented in a compaction simulator and rotary tablet press using three lubricants (magnesium stearate (MgSt), sodium stearyl fumarate (SSF) and glyceryl dibehenate (DBHG)).

In conclusion, the potential of external lubrication for implementation on production scale tableting equipment and during scale-up was demonstrated for multiple lubricants.

More information in the papers section.

You can also find related papers on externa lubrication:

•    Screening of lubricants towards their applicability for external lubrication
• ·  Effect of binder type and lubrication method on the binder efficacy for direct compression
• ·  Evaluation of an external lubrication system implemented in a compaction simulator

Oral dosage specialist CDMO Skyepharma Productions S.A.S. (Skyepharma) has collaborated with Bordeaux University to study the influence of geometrical and process parameters on the release attributes of press-coated tablets. The work potentially enables oral solid dose (OSD) forms to vary lag-time ingredient release profiles while retaining a constant formulation.

Key points for the study:

*Influence of process parameters

*Observing opening modes

*Alternative drug release adjustment

Full news available here.

To know more about controlled release, request access to our webinar replay on tab-in-tab formulations on STYL’One Evo

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R&D tablet presses are an essential part of the laboratory, providing complete tablet compression functionality from a compact system. Using advanced tableting instrumentation, formulation scientists can perform feasibility experiments that help to improve yields and secure product scale-up later on.

6 things to look for when choosing an R&D tablet press

1. Scalability

Scaling up a tableting process from R&D to production can be challenging, with formulation problems likely to arise in the form of tablet defects. Advanced R&D presses help to prevent issues by mimicking the tablet compression characteristics of high-speed production equipment.

2. Return on investment

The right tablet press should result in significant cost savings for your business. It is important to choose a system with comprehensive data acquisition and analysis software. This can help to evaluate tablet quality and develop more robust formulations, meaning less defects and downtime during production.

3. Versatility

Finding a versatile R&D tablet press is key for flexible drug development. With one compaction simulator, you have access to several production processes in one place. You can simulate all the high-speed production presses or roller compactors on the market, so this means versatility.

4. Ease of use

Tablet compression and powder characterisation technology is inherently complex, but it shouldn’t seem so to users. Most vendors will claim to offer intuitive software, so it’s important to consider what actions were taken during development to ensure this.

5. Operator safety

With pharma’s increasing use of highly potent active pharmaceutical ingredients (HPAPIs), purchasing tablet presses with containment features is becoming more and more critical.

6. Strong Service Network

Every so often, maintenance is recommended to keep your tablet press running smoothly across a long service life. “Reactivity in case of issues is key.” In the time-pressured environment of pharma R&D, slow service from your tablet press partner could set you back in time and money.

Read the full article here.  

Helium pycnometry, a commonly used technique for measuring the true density of powders, is sensitive to the release of volatiles during measurement. This can lead to over-estimated true density, and as such, an accurate method for determining the true density of powders containing volatile components is needed. Here, a method based on in-die compression data obtained with a compaction simulator was assessed.

This novel method was validated using a set of water-free powders. Using crystalline hydrates, we further showed that the calculated true densities were closer to values calculated from crystal structure than those from helium pycnometry. Hence, this method may be used for determining the true density of powders from their STC values.

More information in the papers section.