The present work investigate the correlation between critical granules characters (including particle size, surface roughness, and apparent porosity) and mechanical properties of press-coated tablets. The study is available in the PAPERS section.

Find others papers here and learn about

• Immediate-Release Formulations Produced via Twin-Screw Melt Granulation: Systematic Evaluation of the Addition of Disintegrants
  
• Development and pharmaceutical performance of a novel co-processed excipient of alginic acid and microcrystalline cellulose
  
• Influence of binder attributes on binder effectiveness in a continuous twin screw wet granulation process via wet and dry binder addition
  

Replay of the webinar 

--> MySTYL'One members: access the webinar page for the full replay

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Access the replay of the webinar "Fundamental Investigations on Bilayer tablets - Effects of Process Parameters and Geometry on Interfacial Strength" with thanks to the links above.

Speakers:
*Jan Finke, Division Head Pharma & Bioparticle Technology, iPAT, TU Braunschweig & Senior Scientist, Fraunhofer IST
*Bruno Leclercq, Science Lab Head and Business Development Manager, MEDELPHARM

Webinar agenda: 

• Measurement of interfacial adhesion strength 
• Influence of material deformation behaviour & impact of process parameters and tablet geometry
• Detection of signs of internal stresses before delamination 
• Demonstration of multilayer tablet formulation on STYL'One Evo compaction simulator

Why should you watch?

• Learn about fundamental challenges when developping multilayer tablets
• Learn about layer adhesion of bi-layer tablets
• Learn how to develop a multilayer formulation with a compaction simulator
• Determine optimal process parameters for multilayer tablets in little time with only a few grams of material

In the current study, alternative lubricants to MgSt were compared with regard to lubrication efficacy and their impact on tablet properties. The study is available in the PAPERS section.

Find others papers here and learn about

• Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis Bullosa
  
• Tablet formulation development focusing on the functional behaviour of water uptake and swelling
  
• Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter
  

Access the transcript of the webinar "Fundamental Investigations on Bilayer tablets - Effects of Process Parameters and Geometry on Interfacial Strength" 

Speakers:
*Jan Finke, Division Head Pharma & Bioparticle Technology, iPAT, TU Braunschweig & Senior Scientist, Fraunhofer IST
*Bruno Leclercq, Science Lab Head and Business Development Manager, MEDELPHARM

Webinar agenda: 

• General Introduction
• Measurement of interfacial adhesion strength 
• Influence of material deformation behaviour & impact of process parameters and tablet geometry
• Detection of signs of internal stresses before delamination 

The present work summarizes select methodology of twin-screw melt granulation (TSMG) and process analytical technology that were used in the successful scaling-up and commercial transfer of high drug load (80.5% w/w) immediate release fevipiprant tablets. The study is available in the PAPERS section.

Find others papers here and learn about

• Roller Compaction Scale-Up Made Simple: An Approximate Analytical Solution to Johanson's Rolling Theory
  
• Integrating QbD Tools for Flexible Scale-Up Batch Size Selection for Solid Dosage Forms
  
• Model-based approach to the design of pharmaceutical roller-compaction processes