MySTYL'One
Nov. 8, 2021
This new study from the University of Minnesota and Tsinghua University in Beijing shows the development of an immediate release tablet with improved oral bioavailability thanks to an amorphous solid dispersion (ASD) of sorafenib (SOR) in hydroxypropyl methylcellulose acetate succinate (HPMC-AS), prepared by coprecipitation. Access the paper here.
#Tablet #sorafenib #'amorphous solid dispersion' #coprecipitation #'Oral Bioavailibility'
www.patheon.com
Nov. 8, 2021
STYL'One users are in the news!
To be found on Patheon's website, a bulletin on the importance of designing design scalability into formulations from very early on, to mitigate mitigate some of the challenges that arise in Phase III.
More info here.
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MySTYL'One
Oct. 4, 2021
MySTYL'One user exclusive!
Head to the bulletins section and read on how STYL’One Nano can be used to demonstrate material properties, secure formulation development and their product marketing.
Gabrielle Dupont
Sept. 14, 2021
Help us feed the Community library, by sending us your papers, posters or news on tableting.
Bruno Villa
Sept. 10, 2021
WHY IS DRY GRANULATION SO POPULAR THESE DAYS?
Granulation of pharmaceutical powder is often required to prevent segregation of the Active Pharmaceutical Ingredient (API) and/or to enhance the blend flowability, which is critical to ensure consistent tablet mass (weight) on rotary tablet presses. Dry granulation has been known for decades. The main benefit is a lower cost of operation compared to wet granulation. But most interestingly, it’s much easier to contain a roller compactor to process ...
WHY IS DRY GRANULATION SO POPULAR THESE DAYS?
Granulation of pharmaceutical powder is often required to
prevent segregation of the Active Pharmaceutical Ingredient
(API) and/or to enhance the blend flowability, which is critical
to ensure consistent tablet mass (weight) on rotary tablet
presses.
Dry granulation has been known for decades. The main benefit
is a lower cost of operation compared to wet granulation.
But most interestingly, it’s much easier to contain a roller compactor to process high potent drugs. It’s also a truly
continuous process, which is a big trend these days. One have
to point out that in the past decade, equipment manufacturers
have introduced more instrumentation and advanced control
systems, such as Gerteis or LB Bohle to name a few, allowing
a more consistent density on the ribbons through a gap control
loop system
MySTYL'One
Sept. 9, 2021
Pharmaceutical Contract Development and Manufacturing Organizations (CDMO) and Contract Research Organisations (CRO) have been booming in the last years, thanks to an increase in pharmaceuticals activities and booming innovations driving investors. The article describes the Outlook in 2022 and beyond.
www.pharmatec.be
Sept. 7, 2021
Spotted across the web an efficient summary of the Pro's and Con's of adding MgSt directly into the product blend vs external lubrication.
Discover the explanatory table directly on Pharmatec's website www.pharmatec.com
www.korsch.com
Sept. 6, 2021
“The manufacturing of multilayer tablets may seem to be simple duplications of the basic single-layer compression cycle, but in reality, the process is far more complicated. In this article, KORSCH outlines the key considerations in the production of multilayer tablets and defines the key parameters for multilayer process optimization.” Click here for full article