Newsroom, your daily review

Keep up with the latest in the tableting community!


Announcement

MySTYL'One

Dec. 10, 2020

Tableting of mini-tablets in comparison with conventionally sized tablets: A comparison of tableting properties and tablet dimensions

In direct follow up of the webinar of Dec. 10th, take a look at the latest paper published by Ard Lura (Heinrich Heine University, Düsseldorf) : "Tableting of mini-tablets in comparison with conventionally sized tablets".

Full paper is available for download here,

and Ard Lura's ready to answer your various questions on the MySTYL'One Forum.

#comparison #tablet dimensions #mini-tablets #tablet properties

Feature article

MySTYLOne

Dec. 7, 2020

Powder On - kick off meeting!

Powder On holds its kick off meeting on Dec 10th, and you can register to this online event.

Powder On is the Center of Development and Innovation on Pharmaceutical Powder Technology,

headquartered in Dijon, Burgundy.

Read on the news for more info and for the full agenda of the kick of meeting.



#dijon #Powder on #technopole

Feature article

MySTYL'One

Nov. 25, 2020

Webinar Dec 9th: "Mini-tableting on a STYL'One"

Save the date and register for our first webinar!

"R&D of mini-tablets on STYL'One Evo" - by Ard Lura, Henrich Heine University, Düsseldorf (DE)

Register now for this online event, held on Dec 9th, 2020.

Dec 10th update: The event is now over. More infos & retranscript to come soon on MySTYL'One

#webinar #STYLOne #mini-tableting

Press review

www.manufacturingchemist.com

Nov. 24, 2020

First impressions: Tablet shape can impact patient acceptance

One new interesting article we've discovered on manufacturingchemist.com, dealing with tablet design and its impact on patient acceptance.

What would be the benefits of a flat faced radius edge tablet design as compared to a flat faced bevel edge?

Full article is online here



#tablet #Design principles

Press review

www.pharmaceuticaonline.com

Nov. 19, 2020

Reshoring A Nation's API And Pharmaceutical Production

A new press article, spotted on pharmaceuticalonline.com, dealing with the issue of supply chain disruptions driven by the COVID-19 and their consequences.

Will we turn our back on the global supply chain approach? What are the challenges of offshoring and of reshoring?

Full article to be read here



#API #press review #supply

Announcement

MySTYL'One

Nov. 16, 2020

Towards better understanding of the influence of process parameters in roll compaction/dry granulation on throughput, ribbon microhardness and granule failure load

New paper! Head to the papers page to read the article published by Invite GmbH & the University of Düsseldorf.

The study points out the importance of material hardness & how it can be predicted thanks to the process parameters of roll compaction :

  • Specific compaction force
  • Roll speed
  • Gap width

For the 1st time, 2 depending process parameters were used to predict granule failure load :

  • Torque of the granulation unit
  • Throughput of the material

The hardness of the granule was ...

New paper! Head to the papers page to read the article published by Invite GmbH & the University of Düsseldorf.

The study points out the importance of material hardness & how it can be predicted thanks to the process parameters of roll compaction :

  • Specific compaction force
  • Roll speed
  • Gap width

For the 1st time, 2 depending process parameters were used to predict granule failure load :

  • Torque of the granulation unit
  • Throughput of the material

The hardness of the granule was controlled in-line when the specific compaction force was increased during compaction. This process introduces in-line control of material hardness.

#continuous manufacturing #process analytical technologies #process monitoring #granule strength #roll compaction #failure load #microhardness #dry granulation

Announcement

MySTYL'One

Nov. 11, 2020

Evaluation of an external lubrication system implemented in a compaction simulator

We're delighted to announce the recent publication of Cedrine de Backere's first paper. Cedrine is a STYL'One user, and team member of Ghent University's Lab of Pharmaceutical Technology.

This study evaluated the performance of an external lubrication system implemented in a compaction simulator, studing both spraying-time and atomizing pressure.

Low ejection forces were obtained with a much lower lubricant concentration (0.01–0.06% MgSt) compared to internal lubrication (0.75% and/or 1.25% MgS...

We're delighted to announce the recent publication of Cedrine de Backere's first paper. Cedrine is a STYL'One user, and team member of Ghent University's Lab of Pharmaceutical Technology.

This study evaluated the performance of an external lubrication system implemented in a compaction simulator, studing both spraying-time and atomizing pressure.

Low ejection forces were obtained with a much lower lubricant concentration (0.01–0.06% MgSt) compared to internal lubrication (0.75% and/or 1.25% MgSt). In addition, externally lubricated tablets showed no reduced tensile strength and no prolonged disintegration times, which is in contrast to internal lubrication.

Go to the papers page to get further insights, contact her through the directory and react on the forum!

#Gent University #magnesium stearate #paper #lubrication #compaction simulator

Feature article

MySTYL'One

Nov. 2, 2020

Replay (Part 2) - STYL'One, a new approach to formulate tablets (Q&A session)

Read on the 2nd part of the transcript of MEDELPHARM's first live webinar on STYL'One technology.

On Tue. October 6th, Bruno Leclercq and Quentin Boulay presented STYL'One compaction simulation technologies and range of products to users and non-users of STYL'One .

The presentation was followed by a Q&A session on subjects ranging from lamination to minitablet weight consistency, external lubrication, ribbons, rotary tooling, punch force and tensile strength.

The full video of the webinar is...

Read on the 2nd part of the transcript of MEDELPHARM's first live webinar on STYL'One technology.

On Tue. October 6th, Bruno Leclercq and Quentin Boulay presented STYL'One compaction simulation technologies and range of products to users and non-users of STYL'One .

The presentation was followed by a Q&A session on subjects ranging from lamination to minitablet weight consistency, external lubrication, ribbons, rotary tooling, punch force and tensile strength.

The full video of the webinar is still available here, or you can take a quick glance at the Q&A transcript below.

#Q&A #webinar #STYLOne #compaction simulator

Press review

MySTYL'One

Oct. 30, 2020

Available on demand: Layer by Layer: the Fundamentals of multi-layer tableting

JRS pharma's R&D director Anthony Carpanzano explains the essentials of this easy and cost-saving solution. Get insights and information on:

- formulation possibilities

- the tableting process

- key elements to take into account: tooling, layer design, tamping force adjustments etc.

Access the webcast replay HERE

#multilayer #formulation #tableting #webinar

Press review

MySTYL'One

Oct. 30, 2020

Roller compaction: new trends, challenges and solutions

Read the article from Catalent explaining the 3 known technologies to develop tablets:

- direct compression
- wet granulation
- dry granulation, 

with a focus on roller compaction, as it remains an effective solution for most APIs, in particular those as amorphous solid dispersions.

#direct compression #dry granulation #Roller compaction #wet granulation

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