May 10, 2023

The distribution of Drucker-Prager Cap model parameters for pharmaceutical materials

This work summarizes the findings from the collection of DPC parameters from 60 materials. From this dataset several important conclusions can be drawn about typical and extreme behaviors of formulations and excipients. From these findings key signals of program risk can be determined and utilized early in the formulation development process to avoid costly manufacturing and scale-up issues.

The paper is available in the PAPERS section.

Find others studies here using the Drucker-Prager Cap model:

• Predictive modelling of powder compaction for binary mixtures using the finite element method
• Comparative study between Drucker-Prager/Cap and modified Cam-Clay models for the numerical simulation of die compaction of pharmaceutical powders

#finite elements methods #STYL'One #compaction #Drucker-Prager Cap model #DPC

April 28, 2022

Predictive modelling of powder compaction for binary mixtures using the finite element method

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The present work details powder compaction simulations, using the finite element method (FEM) in combination with the density-dependent Drucker-Prager Cap model, which can be used to aid the design process of pharmaceutical tablets. Full paper available in the PAPERS section.

Find others papers here and learn about

• Breaking patterns of press-coated tablets during the diametral compression test: Influence of the product, geometry and process parameters
• Novel ultrasonic in-die measurements during powder compression at production relevant speed
  
• Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces
  

#formulation #Predictive modelling #mechanical properties #Mixing model #Powder compaction #STYLOne #Drucker-Prager Cap model