MySTYL'One
June 15, 2021
A new paper published by the university of Düsseldorf on the compression of Metformin Hydrochloride, a drug which had before not been directly compressed. However using a quasi-emulsion solvent-diffusion (QESD) crystallization technique allows for better flowability and reduce storage agglomeration, making direct compression possible after evaluating the tabletability of the material.
Full paper available here.
#direct compression #'Metformin Hydrochloride' #'tablet capping' #precompression #'spherical crystallization' #STYLOne #flowability
MySTYL'One
Nov. 2, 2020
Read on the 2nd part of the transcript of MEDELPHARM's first live webinar on STYL'One technology.
On Tue. October 6th, Bruno Leclercq and Quentin Boulay presented STYL'One compaction simulation technologies and range of products to users and non-users of STYL'One .
The presentation was followed by a Q&A session on subjects ranging from lamination to minitablet weight consistency, external lubrication, ribbons, rotary tooling, punch force and tensile strength.
The full video of the webinar is...
Read on the 2nd part of the transcript of MEDELPHARM's first live webinar on STYL'One technology.
On Tue. October 6th, Bruno Leclercq and Quentin Boulay presented STYL'One compaction simulation technologies and range of products to users and non-users of STYL'One .
The presentation was followed by a Q&A session on subjects ranging from lamination to minitablet weight consistency, external lubrication, ribbons, rotary tooling, punch force and tensile strength.
The full video of the webinar is still available here, or you can take a quick glance at the Q&A transcript below.
Bruno Leclercq
Sept. 29, 2020
Lubricants are often required to minimize friction between a tablet surface and the die walls during the ejection phase of the compression cycle. In turn the reduced friction minimizes the wear of punches and dies and avoid that tablets are stressed and damaged when ejected from the die cavity. Besides decreasing the friction that has often been described as the true role of a lubricant, lubricants can also serve as anti-adherent and glidant.
To specifically solve sticking and flowability issues, other excipients should be used, such as talc and colloidal silicon dioxide, respectively. Lubricants are a key excipient category in solid formulations but they can also lead to loss of tablet breaking force as well as slow down of dissolution. In order to maintain ejections forces as low as possible while minimizing the negative impact on tablet hardness and dissol...