MySTYL'One
May 24, 2022
The present work details how moisture sorption properties of the starches with different amylose-amylopectin ratio impacted tablet properties including drug stability. Full paper available in the PAPERS section.
Find others papers here and learn about
The present work details how moisture sorption properties of the starches with different amylose-amylopectin ratio impacted tablet properties including drug stability. Full paper available in the PAPERS section.
Find others papers here and learn about
#stability #tableting #moisture #Amylose #STYLOne #Amylopectin
MySTYL'One
May 9, 2022
The present work details a model based on the Ryshkewitch-Duckworth equation that can estimate the compactibility profiles of lubricated formulations. Available model showing extended quantitative predictive accuracy for the influence of lubricant concentration on the mechanical strength of tablets. Full paper available in the PAPERS section.
Find others papers here and learn about
The present work details a model based on the Ryshkewitch-Duckworth equation that can estimate the compactibility profiles of lubricated formulations. Available model showing extended quantitative predictive accuracy for the influence of lubricant concentration on the mechanical strength of tablets. Full paper available in the PAPERS section.
Find others papers here and learn about
#tableting #Modeling #Multi-component compaction #Mechanical strength #STYLOne #lubrication
MySTYL'One
April 28, 2022
The present work details powder compaction simulations, using the finite element method (FEM) in combination with the density-dependent Drucker-Prager Cap model, which can be used to aid the design process of pharmaceutical tablets. Full paper available in the PAPERS section.
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#formulation #Predictive modelling #mechanical properties #Mixing model #Powder compaction #STYLOne #Drucker-Prager Cap model
MySTYL'One
April 26, 2022
The present work in mechanistic process modeling presents an opportunity to reduce experimental burden, enabling relationships between process parameters and product attributes to be mapped out using in-silico experiments. Full paper available in the PAPERS section.
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#Design space #Pharmaceutical process #STYLOne #System model #Formulation design
MySTYL'One
April 18, 2022
The present work details the challenges associated with material attributes during drug product process development, process modification, and life cycle management. Full paper available in the PAPERS section.
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MySTYL'One
Nov. 2, 2020
Read on the 2nd part of the transcript of MEDELPHARM's first live webinar on STYL'One technology.
On Tue. October 6th, Bruno Leclercq and Quentin Boulay presented STYL'One compaction simulation technologies and range of products to users and non-users of STYL'One .
The presentation was followed by a Q&A session on subjects ranging from lamination to minitablet weight consistency, external lubrication, ribbons, rotary tooling, punch force and tensile strength.
The full video of the webinar is...
Read on the 2nd part of the transcript of MEDELPHARM's first live webinar on STYL'One technology.
On Tue. October 6th, Bruno Leclercq and Quentin Boulay presented STYL'One compaction simulation technologies and range of products to users and non-users of STYL'One .
The presentation was followed by a Q&A session on subjects ranging from lamination to minitablet weight consistency, external lubrication, ribbons, rotary tooling, punch force and tensile strength.
The full video of the webinar is still available here, or you can take a quick glance at the Q&A transcript below.
Bruno Leclercq
Sept. 29, 2020
Lubricants are often required to minimize friction between a tablet surface and the die walls during the ejection phase of the compression cycle. In turn the reduced friction minimizes the wear of punches and dies and avoid that tablets are stressed and damaged when ejected from the die cavity. Besides decreasing the friction that has often been described as the true role of a lubricant, lubricants can also serve as anti-adherent and glidant.
To specifically solve sticking and flowability issues, other excipients should be used, such as talc and colloidal silicon dioxide, respectively. Lubricants are a key excipient category in solid formulations but they can also lead to loss of tablet breaking force as well as slow down of dissolution. In order to maintain ejections forces as low as possible while minimizing the negative impact on tablet hardness and dissol...