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Showing posts tagged as : #STYLOne

Announcement

MySTYL'One

May 24, 2022

Impact of Amylose-Amylopectin Ratio of Starches on the Mechanical Strength and Stability of Acetylsalicylic Acid Tablets


The present work details how moisture sorption properties of the starches with different amylose-amylopectin ratio impacted tablet properties including drug stability. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Compression Profiles of a Directly Compressible Starch using Compaction Simulation and High-Speed Tablet Press
  • Insights into the Moisture Scavenging Properties of Different Types of Starch in Tablets Containing a Moisture-Sensitive Drug
  • Starch-based...

The present work details how moisture sorption properties of the starches with different amylose-amylopectin ratio impacted tablet properties including drug stability. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Compression Profiles of a Directly Compressible Starch using Compaction Simulation and High-Speed Tablet Press
  • Insights into the Moisture Scavenging Properties of Different Types of Starch in Tablets Containing a Moisture-Sensitive Drug
  • Starch-based controlled release matrix tablets: Impact of the type of starch

#stability #tableting #moisture #Amylose #STYLOne #Amylopectin

Announcement

MySTYL'One

May 9, 2022

Prediction of the impact of lubrication on tablet compactibility


The present work details a model based on the Ryshkewitch-Duckworth equation that can estimate the compactibility profiles of lubricated formulations. Available model showing extended quantitative predictive accuracy for the influence of lubricant concentration on the mechanical strength of tablets. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Effect of binder type and lubrication method on the binder efficacy for direct compression
  • Evaluation of an externa...

The present work details a model based on the Ryshkewitch-Duckworth equation that can estimate the compactibility profiles of lubricated formulations. Available model showing extended quantitative predictive accuracy for the influence of lubricant concentration on the mechanical strength of tablets. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Effect of binder type and lubrication method on the binder efficacy for direct compression
  • Evaluation of an external lubrication system implemented in a compaction simulator
  • External lubrication system on the Styl’One Evolution

#tableting #Modeling #Multi-component compaction #Mechanical strength #STYLOne #lubrication

Announcement

MySTYL'One

April 28, 2022

Predictive modelling of powder compaction for binary mixtures using the finite element method


The present work details powder compaction simulations, using the finite element method (FEM) in combination with the density-dependent Drucker-Prager Cap model, which can be used to aid the design process of pharmaceutical tablets. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Breaking patterns of press-coated tablets during the diametral compression test: Influence of the product, geometry and process parameters
  • Novel ultrasonic in-die measurements during powder compression at production relevant speed
  • Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces

#formulation #Predictive modelling #mechanical properties #Mixing model #Powder compaction #STYLOne #Drucker-Prager Cap model

Announcement

MySTYL'One

April 26, 2022

System model driven selection of robust tablet manufacturing processes based on drug loading and formulation physical attributes


The present work in mechanistic process modeling presents an opportunity to reduce experimental burden, enabling relationships between process parameters and product attributes to be mapped out using in-silico experiments. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Investigating key properties of model excipients and binary powder blends using ultrasonic in-die measurements on a compaction simulator 
  • Impact of Incorporated Drugs on Material Properties of Amorphous Solid Dispersions
  • Systematic approach to elucidate compaction behavior of acyclovir using a compaction simulator

#Design space #Pharmaceutical process #STYLOne #System model #Formulation design

Announcement

MySTYL'One

April 18, 2022

Challenges and Solutions in Drug Product Process Development from a Material Science Perspective


The present work details the challenges associated with material attributes during drug product process development, process modification, and life cycle management. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Partial tablet coating by 3D printing
  • Gluing Pills Technology: A novel route to multilayer tablet manufacturing

#Powder #STYLOne #Material science #Quality by Design

Feature article

MySTYL'One

Nov. 2, 2020

Replay (Part 2) - STYL'One, a new approach to formulate tablets (Q&A session)

Read on the 2nd part of the transcript of MEDELPHARM's first live webinar on STYL'One technology.

On Tue. October 6th, Bruno Leclercq and Quentin Boulay presented STYL'One compaction simulation technologies and range of products to users and non-users of STYL'One .

The presentation was followed by a Q&A session on subjects ranging from lamination to minitablet weight consistency, external lubrication, ribbons, rotary tooling, punch force and tensile strength.

The full video of the webinar is...

Read on the 2nd part of the transcript of MEDELPHARM's first live webinar on STYL'One technology.

On Tue. October 6th, Bruno Leclercq and Quentin Boulay presented STYL'One compaction simulation technologies and range of products to users and non-users of STYL'One .

The presentation was followed by a Q&A session on subjects ranging from lamination to minitablet weight consistency, external lubrication, ribbons, rotary tooling, punch force and tensile strength.

The full video of the webinar is still available here, or you can take a quick glance at the Q&A transcript below.

#Q&A #webinar #STYLOne #compaction simulator

Feature article

Bruno Leclercq

Sept. 29, 2020

Lubrication now easy-to-use for R&D lab environment

Lubricants are often required to minimize friction between a tablet surface and the die walls during the ejection phase of the compression cycle. In turn the reduced friction minimizes the wear of punches and dies and avoid that tablets are stressed and damaged when ejected from the die cavity. Besides decreasing the friction that has often been described as the true role of a lubricant, lubricants can also serve as anti-adherent and glidant.

To specifically solve sticking and flowability issues, other excipients should be used, such as talc and colloidal silicon dioxide, respectively. Lubricants are a key excipient category in solid formulations but they can also lead to loss of tablet breaking force as well as slow down of dissolution. In order to maintain ejections forces as low as possible while minimizing the negative impact on tablet hardness and dissol...

#STYLOne #magnesium stearate #lubrication #MIST

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