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Showing posts tagged as : #STYLOne

Announcement

MySTYL'One

Jan. 19, 2023

Compressibility analysis as robust in-die compression analysis for describing tableting behaviour


In this paper you will find an investigation on the compressibility constant as an in-die method and has been compared with the Heckel analysis for describing the compressibility of materials during tableting. The paper is available in the PAPERS section.

Find others papers here and learn about

  • Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter
  • Process Modeling and Simulation of Tableting—An Agent-Based Simulation Methodology for Direct Compression
  • Immediate-Re...

In this paper you will find an investigation on the compressibility constant as an in-die method and has been compared with the Heckel analysis for describing the compressibility of materials during tableting. The paper is available in the PAPERS section.

Find others papers here and learn about

  • Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter
  • Process Modeling and Simulation of Tableting—An Agent-Based Simulation Methodology for Direct Compression
  • Immediate-Release Formulations Produced via Twin-Screw Melt Granulation: Systematic Evaluation of the Addition of Disintegrants

#direct compression #compression analysis #sensitivity analysis #compressibility constant #heckel #STYLOne

Feature article

MySTYL'One

Dec. 19, 2022

Webinar replay - Dosage Form Design & Patient Compliance: Exploring ODTs as a Patient-centric Solution

Get access for this online event replay.

Date: Friday, January 27th, 2022
Time: 11am EST/4PM GMT/8am PST
Duration: 60 minutes

"Dosage Form Design & Patient Compliance: Exploring ODTs as a Patient-centric Solution" - by David Elder, Principal Consultanl - David P Elder Consultancy, and Ralph Gosden, Head of Zydis Product Development - Catalent.

#webinar #STYLOne #catalent #dosage form

Announcement

MySTYL'One

June 20, 2022

Impact of unloading kinematics on the occurrence of capping during the production of pharmaceutical tablets


The present work details the influence of the unloading step on capping using a compaction simulator. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Studying the impact of lubrication on tablet properties using STYL'One
  • The effect of spray drying on the compaction properties of hypromellose acetate succinate

#tableting #capping #compression #STYLOne #tablet #Defects

Announcement

MySTYL'One

June 6, 2022

Pharmacotechnical Evaluation by SeDeM Expert System to Develop Orodispersible Tablets


The present work details solubility of BCS class II, nevirapine using solid dispersions, SeDeM analyses of excipients and solid dispersions to analyze direct compressibility  and orodispersibility tablets (ODT).

Find others papers here and learn about

  • Structure-Property Relationship of Amorphous Maltitol as Tableting Excipient
  • Evaluation of an external lubrication system implemented in a compaction simulator

#Orodispersible Tablets #superdisintegrants #antiretrovirals #micromeritics #nevirapine #SeDeM #STYLOne

Announcement

MySTYL'One

June 2, 2022

Manufacturing of mini-tablets. Focus and impact of the tooling systems


The present work details the effect of the used tooling system on quality attributes during manufacturing mini-tablets. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Transfer and scale-up of the manufacturing of orodispersible mini-tablets from a compaction simulator to an industrial rotary tablet press
  • Investigation of critical factors affecting mechanical characteristics of press-coated tablets using a compaction simulator
  • Along the Process Chain to Probiot...

The present work details the effect of the used tooling system on quality attributes during manufacturing mini-tablets. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Transfer and scale-up of the manufacturing of orodispersible mini-tablets from a compaction simulator to an industrial rotary tablet press
  • Investigation of critical factors affecting mechanical characteristics of press-coated tablets using a compaction simulator
  • Along the Process Chain to Probiotic Tablets: Evaluation of Mechanical Impacts on Microbial Viability

#single-tip #multi-tip #Tooling system #compaction simulator #STYLOne #mini-tablets #Tableting properties

Announcement

MySTYL'One

May 24, 2022

Impact of Amylose-Amylopectin Ratio of Starches on the Mechanical Strength and Stability of Acetylsalicylic Acid Tablets


The present work details how moisture sorption properties of the starches with different amylose-amylopectin ratio impacted tablet properties including drug stability. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Compression Profiles of a Directly Compressible Starch using Compaction Simulation and High-Speed Tablet Press
  • Insights into the Moisture Scavenging Properties of Different Types of Starch in Tablets Containing a Moisture-Sensitive Drug
  • Starch-based...

The present work details how moisture sorption properties of the starches with different amylose-amylopectin ratio impacted tablet properties including drug stability. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Compression Profiles of a Directly Compressible Starch using Compaction Simulation and High-Speed Tablet Press
  • Insights into the Moisture Scavenging Properties of Different Types of Starch in Tablets Containing a Moisture-Sensitive Drug
  • Starch-based controlled release matrix tablets: Impact of the type of starch

#stability #tableting #moisture #Amylose #STYLOne #Amylopectin

Announcement

MySTYL'One

May 9, 2022

Prediction of the impact of lubrication on tablet compactibility


The present work details a model based on the Ryshkewitch-Duckworth equation that can estimate the compactibility profiles of lubricated formulations. Available model showing extended quantitative predictive accuracy for the influence of lubricant concentration on the mechanical strength of tablets. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Effect of binder type and lubrication method on the binder efficacy for direct compression
  • Evaluation of an externa...

The present work details a model based on the Ryshkewitch-Duckworth equation that can estimate the compactibility profiles of lubricated formulations. Available model showing extended quantitative predictive accuracy for the influence of lubricant concentration on the mechanical strength of tablets. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Effect of binder type and lubrication method on the binder efficacy for direct compression
  • Evaluation of an external lubrication system implemented in a compaction simulator
  • External lubrication system on the Styl’One Evolution

#tableting #Modeling #Multi-component compaction #Mechanical strength #STYLOne #lubrication

Announcement

MySTYL'One

April 28, 2022

Predictive modelling of powder compaction for binary mixtures using the finite element method


The present work details powder compaction simulations, using the finite element method (FEM) in combination with the density-dependent Drucker-Prager Cap model, which can be used to aid the design process of pharmaceutical tablets. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Breaking patterns of press-coated tablets during the diametral compression test: Influence of the product, geometry and process parameters
  • Novel ultrasonic in-die measurements during ...

The present work details powder compaction simulations, using the finite element method (FEM) in combination with the density-dependent Drucker-Prager Cap model, which can be used to aid the design process of pharmaceutical tablets. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Breaking patterns of press-coated tablets during the diametral compression test: Influence of the product, geometry and process parameters
  • Novel ultrasonic in-die measurements during powder compression at production relevant speed
  • Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces

#formulation #Predictive modelling #mechanical properties #Mixing model #Powder compaction #STYLOne #Drucker-Prager Cap model

Announcement

MySTYL'One

April 26, 2022

System model driven selection of robust tablet manufacturing processes based on drug loading and formulation physical attributes


The present work in mechanistic process modeling presents an opportunity to reduce experimental burden, enabling relationships between process parameters and product attributes to be mapped out using in-silico experiments. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Investigating key properties of model excipients and binary powder blends using ultrasonic in-die measurements on a compaction simulator 
  • Impact of Incorporated Drugs on Material Properties of ...

The present work in mechanistic process modeling presents an opportunity to reduce experimental burden, enabling relationships between process parameters and product attributes to be mapped out using in-silico experiments. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Investigating key properties of model excipients and binary powder blends using ultrasonic in-die measurements on a compaction simulator 
  • Impact of Incorporated Drugs on Material Properties of Amorphous Solid Dispersions
  • Systematic approach to elucidate compaction behavior of acyclovir using a compaction simulator

#Design space #Pharmaceutical process #STYLOne #System model #Formulation design

Announcement

MySTYL'One

April 18, 2022

Challenges and Solutions in Drug Product Process Development from a Material Science Perspective


The present work details the challenges associated with material attributes during drug product process development, process modification, and life cycle management. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Partial tablet coating by 3D printing
  • Gluing Pills Technology: A novel route to multilayer tablet manufacturing

#Powder #STYLOne #Material science #Quality by Design

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