New paper added on MySTYL’One.

The formulation development of amorphous solid dispersions (ASDs) towards a patient-friendly oral solid dosage form is proving to be still challenging. To increase patient’s compliance orodispersible tablets (ODTs) can be seen as promising alternative. Two different ASDs were prepared via hot melt extrusion (HME), using PVPVA as polymer for ritonavir (RTV) and HPMCAS for lopinavir (LPV). The extrudates were also milled, sieved, and blended.

Conclusions

• The selected ASD particle size was pointed out to be a key parameter for a fast disintegration and high mechanical strength.
• In terms of PVPVA based ASDs, larger particle sizes > 500 µm enabled a rapid disintegration even under 30 s for 50 % ASD loaded ODTs
• The use of smaller particles went along with significant higher disintegration times
• The influence of the CPE was immense for PVPVA based ASDs
•  In contrast for HPMCAS based ASDs the selection of smaller particle sizes 180–500 µm was beneficial for overcoming the poor compressibility of the ASD matrix polymer

The University of Copenhagen presents a work on an approach for development of the optimal tablet formulation as well as gaining an understanding on how the selection of excipients and manufacturing processes ultimately influences tablet disintegration.Medelpharm is part of this innovative project. Full paper available in the PAPERS section.

Find others papers here and learn about

• Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces
  
• Predictive selection rule of favourable image processing methods for X-ray micro-computed tomography images of tablets
  
• Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis Bullosa