Jan. 4, 2022

Comparison of Hydroxypropylcellulose and Hot-Melt Extrudable Hypromellose in Twin-Screw Melt Granulation of Metformin Hydrochloride

The purpose of this new study was to evaluate the processability and dissolution behavior of HPC GXF ((Klucel^® GXF) and a recently introduced type of hot-melt extrudable HPMC (Affinisol^®) in extended-release metformin hydrochloride formulations using twin-screw melt granulation. The powder blends were then granulated at different temperatures, then tableted. Rheological studies (steady steer rate viscosity and rotation rheometry) as well as dissolution studies were then performed. Full paper available in the PAPERS section.

#polymer #hydroxypropyl methylcellulose #melt extrusion #hydroxypropyl cellulose #rheology #twin screw melt granulation #binder #tablet