In this paper you will find a study that focuses on the assessment of the capping problem using computer modelling of the pharmaceutical powder compression and consolidation process using the finite element analysis (FEA) method implementing the Drucker–Prager Cap (DPC) model. The paper is available in the PAPERS section.

Find others papers here and learn about

• Characterization of Tableting Speed-Dependent Deformation Properties of Active Pharmaceutical Ingredients in Powder Mixtures Using Out-of-Die Method
  
• Influence of the unloading conditions on capping and lamination: Study on a compaction simulator
  
• Shear strength of pharmaceutical tablets: Theoretical considerations, evaluation and relation with the capping tendency of biconvex tablets
  

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Quality by Design (QbD) in tablet development

can be challenging, due to the multiple competing technological aims, such as flow, compactability, lubrication and drug release. Tablets are complex and, whether due to ignorance or indeterminacy, uncertainty also makes it difficult to develop tablets robust enough to cope with scale-up and Production. Speed sensitivity of the compression mix can come as an unwelcome surprise to those who did not know that tablets have speed limits! Speed sensitivity may also be called strain rate sensitivity. The penalty for exceeding the speed limit is capping, making tablet production impossible. During development capping/lamination is unacceptable for further progression.

The present works demonstrated from a study to predict capping on biconvex tablets from a wide range of products (18 formulations, 8 of which presenting capping), using the properties characterized on defect-free flat-faced tablets (tensile strength, solid fraction, elastic recovery, etc.). The study is available in the PAPERS section.

Find others papers here and learn about

• Use of impulse excitation technique for the characterization of the elastic anisotropy of pharmaceutical tablets
  
• Enabling the direct compression of metformin hydrochloride through QESD crystallization
  
• Role of Precompression in the Mitigation of Capping: A Case Study