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Showing posts tagged as : #direct compression



June 15, 2021

Enabling the direct compression of metformin hydrochloride through QESD crystallization

A new paper published by the university of Düsseldorf on the compression of Metformin Hydrochloride, a drug which had before not been directly compressed. However using a quasi-emulsion solvent-diffusion (QESD) crystallization technique allows for better flowability and reduce storage agglomeration, making direct compression possible after evaluating the tabletability of the material.

Full paper available here.  

#direct compression #'Metformin Hydrochloride' #'tablet capping' #precompression #'spherical crystallization' #STYLOne #flowability

Press review


Oct. 30, 2020

Roller compaction: new trends, challenges and solutions

Read the article from Catalent explaining the 3 known technologies to develop tablets:

- direct compression
- wet granulation
- dry granulation, 

with a focus on roller compaction, as it remains an effective solution for most APIs, in particular those as amorphous solid dispersions.

#direct compression #dry granulation #Roller compaction #wet granulation

Press review

July 10, 2020

Which tableting process is right for you?

In this explanatory video Merck compares 3 possibilities for tableting: direct compression, wet granulation and roller compaction/dry granulation, including explanations on the processes and pros & cons of each. 

#direct compression #news #tableting process #roller compaction #wet granulation

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