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Sept. 10, 2021
WHY IS DRY GRANULATION SO POPULAR THESE DAYS?
Granulation of pharmaceutical powder is often required to
prevent segregation of the Active Pharmaceutical Ingredient
(API) and/or to enhance the blend flowability, which is critical
to ensure consistent tablet mass (weight) on rotary tablet
Dry granulation has been known for decades. The main benefit
is a lower cost of operation compared to wet granulation.
But most interestingly, it’s much easier to contain a roller compactor to process high potent drugs. It’s also a truly
continuous process, which is a big trend these days. One have
to point out that in the past decade, equipment manufacturers
have introduced more instrumentation and advanced control
systems, such as Gerteis or LB Bohle to name a few, allowing
a more consistent density on the ribbons through a gap control