June 15, 2021

Enabling the direct compression of metformin hydrochloride through QESD crystallization

A new paper published by the university of Düsseldorf on the compression of Metformin Hydrochloride, a drug which had before not been directly compressed. However using a quasi-emulsion solvent-diffusion (QESD) crystallization technique allows for better flowability and reduce storage agglomeration, making direct compression possible after evaluating the tabletability of the material.

Full paper available here.  

#direct compression #'Metformin Hydrochloride' #'tablet capping' #precompression #'spherical crystallization' #STYLOne #flowability