MySTYL'One
May 11, 2022
MySTYL'One users exclusive!
We're inviting you to chat with Calvin Sun Changquan and Gerrit Vreeman from University of Minnesota on Air entrapment during tablet compression - Diagnosis, impact on tableting performance, and mitigation strategies on Wednesday, May 24th @4:30pm Paris time.
Calvin Sun and Gerrit have published in the International Journal of Pharmaceutics and have studied the role of air entrapment during tablet compression using a compaction simulator. The impact of air entrapment...
MySTYL'One users exclusive!
We're inviting you to chat with Calvin Sun Changquan and Gerrit Vreeman from University of Minnesota on Air entrapment during tablet compression - Diagnosis, impact on tableting performance, and mitigation strategies on Wednesday, May 24th @4:30pm Paris time.
Calvin Sun and Gerrit have published in the International Journal of Pharmaceutics and have studied the role of air entrapment during tablet compression using a compaction simulator. The impact of air entrapment is pressure dependent and deaeration (by applying a pre-compression step) can be an effective mitigation strategy. Though, the degree of improvement depends on the level of pressure applied during pre-compression.
After a short presentation of their paper and results, you can engage in the discussion, ask questions and exchange on the results!
Don't forget your coffee, tea, juice, water...whathever suits!
This online chat is only open to members of MySTYL'One.
#Upscaling #online chat #paper #chat around coffee #lubricant sensitivity #lubrication
MySTYL'One
May 9, 2022
The present work details a model based on the Ryshkewitch-Duckworth equation that can estimate the compactibility profiles of lubricated formulations. Available model showing extended quantitative predictive accuracy for the influence of lubricant concentration on the mechanical strength of tablets. Full paper available in the PAPERS section.
Find others papers here and learn about
The present work details a model based on the Ryshkewitch-Duckworth equation that can estimate the compactibility profiles of lubricated formulations. Available model showing extended quantitative predictive accuracy for the influence of lubricant concentration on the mechanical strength of tablets. Full paper available in the PAPERS section.
Find others papers here and learn about
#tableting #Modeling #Multi-component compaction #Mechanical strength #STYLOne #lubrication
Bruno Leclercq
Sept. 29, 2020
Lubricants are often required to minimize friction between a tablet surface and the die walls during the ejection phase of the compression cycle. In turn the reduced friction minimizes the wear of punches and dies and avoid that tablets are stressed and damaged when ejected from the die cavity. Besides decreasing the friction that has often been described as the true role of a lubricant, lubricants can also serve as anti-adherent and glidant.
To specifically solve sticking and flowability issu...
Lubricants are often required to minimize friction between a tablet surface and the die walls during the ejection phase of the compression cycle. In turn the reduced friction minimizes the wear of punches and dies and avoid that tablets are stressed and damaged when ejected from the die cavity. Besides decreasing the friction that has often been described as the true role of a lubricant, lubricants can also serve as anti-adherent and glidant.
To specifically solve sticking and flowability issues, other excipients should be used, such as talc and colloidal silicon dioxide, respectively. Lubricants are a key excipient category in solid formulations but they can also lead to loss of tablet breaking force as well as slow down of dissolution. In order to maintain ejections forces as low as possible while minimizing the negative impact on tablet hardness and dissol...
Biogrund.com
July 10, 2020
Comparison of lubrication
In this study traditionally used lubricants stearic acid & magnesium stearate were replaced with natural based lubricants (rice extract) or excipient premixes (cellulose/rice extract/oil/wax). The ejection force was measured to determine best lubrication.
#stearic acid #rice extract #ejection force #magnesium stearate #lubrication