MySTYL'One users exclusive!

We're inviting you to chat with Calvin Sun Changquan and Gerrit Vreeman from University of Minnesota on Air entrapment during tablet compression - Diagnosis, impact on tableting performance, and mitigation strategies on Wednesday, May 24th @4:30pm Paris time.

Calvin Sun and Gerrit have published in the International Journal of Pharmaceutics and have studied the role of air entrapment during tablet compression using a compaction simulator. The impact of air entrapment is pressure dependent and deaeration (by applying a pre-compression step) can be an effective mitigation strategy. Though, the degree of improvement depends on the level of pressure applied during pre-compression.

 After a short presentation of their paper and results, you can engage in the discussion, ask questions and exchange on the results! 

Don't forget your coffee, tea, juice, water...whathever suits!

This online chat is only open to members of MySTYL'One.

The present work details a model based on the Ryshkewitch-Duckworth equation that can estimate the compactibility profiles of lubricated formulations. Available model showing extended quantitative predictive accuracy for the influence of lubricant concentration on the mechanical strength of tablets. Full paper available in the PAPERS section.

Find others papers here and learn about

• Effect of binder type and lubrication method on the binder efficacy for direct compression
  
• Evaluation of an external lubrication system implemented in a compaction simulator
  
• External lubrication system on the Styl’One Evolution
  

Lubricants are often required to minimize friction between a tablet surface and the die walls during the ejection phase of the compression cycle. In turn the reduced friction minimizes the wear of punches and dies and avoid that tablets are stressed and damaged when ejected from the die cavity. Besides decreasing the friction that has often been described as the true role of a lubricant, lubricants can also serve as anti-adherent and glidant.

To specifically solve sticking and flowability issues, other excipients should be used, such as talc and colloidal silicon dioxide, respectively. Lubricants are a key excipient category in solid formulations but they can also lead to loss of tablet breaking force as well as slow down of dissolution. In order to maintain ejections forces as low as possible while minimizing the negative impact on tablet hardness and dissol...