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Showing posts tagged as : #lubrication

Feature article

MySTYL'One

Jan. 22, 2021

Webinar Feb17th: "External Lubrication: How to mitigate the impact of lubricants on your quality attributes"

Save the date and register to our upcoming webinar!

"External lubrication: How to mitigate the impact of lubricants on quality attributes" - by Cedrine de Backere, Ghent University (BE)

Registration is now open for this online event, held on Feb. 17th, 2021

Feb 17th update: The event is now over. More infos & transcript to come soon on MySTYL'One.

#webinar #STYLOne #lubrication

Announcement

MySTYL'One

Nov. 11, 2020

Evaluation of an external lubrication system implemented in a compaction simulator

We're delighted to announce the recent publication of Cedrine de Backere's first paper. Cedrine is a STYL'One user, and team member of Ghent University's Lab of Pharmaceutical Technology.

This study evaluated the performance of an external lubrication system implemented in a compaction simulator, studing both spraying-time and atomizing pressure.

Low ejection forces were obtained with a much lower lubricant concentration (0.01–0.06% MgSt) compared to internal lubrication (0.75% and/or 1.25% MgS...

We're delighted to announce the recent publication of Cedrine de Backere's first paper. Cedrine is a STYL'One user, and team member of Ghent University's Lab of Pharmaceutical Technology.

This study evaluated the performance of an external lubrication system implemented in a compaction simulator, studing both spraying-time and atomizing pressure.

Low ejection forces were obtained with a much lower lubricant concentration (0.01–0.06% MgSt) compared to internal lubrication (0.75% and/or 1.25% MgSt). In addition, externally lubricated tablets showed no reduced tensile strength and no prolonged disintegration times, which is in contrast to internal lubrication.

Go to the papers page to get further insights, contact her through the directory and react on the forum!

#Gent University #magnesium stearate #paper #lubrication #compaction simulator

Feature article

Bruno Leclercq

July 28, 2020

Lubrication now easy-to-use for R&D lab environment

Lubricants are often required to minimize friction between a tablet surface and the die walls during the ejection phase of the compression cycle. In turn the reduced friction minimizes the wear of punches and dies and avoid that tablets are stressed and damaged when ejected from the die cavity. Besides decreasing the friction that has often been described as the true role of a lubricant, lubricants can also serve as anti-adherent and glidant.

To specifically solve sticking and flowability issu...

Lubricants are often required to minimize friction between a tablet surface and the die walls during the ejection phase of the compression cycle. In turn the reduced friction minimizes the wear of punches and dies and avoid that tablets are stressed and damaged when ejected from the die cavity. Besides decreasing the friction that has often been described as the true role of a lubricant, lubricants can also serve as anti-adherent and glidant.

To specifically solve sticking and flowability issues, other excipients should be used, such as talc and colloidal silicon dioxide, respectively. Lubricants are a key excipient category in solid formulations but they can also lead to loss of tablet breaking force as well as slow down of dissolution. In order to maintain ejections forces as low as possible while minimizing the negative impact on tablet hardness and dissol...

#STYLOne #magnesium stearate #lubrication #MIST

Press review

Biogrund.com

July 10, 2020

Replacing the lubricants stearic acid or magnesium stearate with lubricants based on natural ingredients

Comparison of lubrication

In this study traditionally used lubricants stearic acid & magnesium stearate were replaced with natural based lubricants (rice extract) or excipient premixes (cellulose/rice extract/oil/wax). The ejection force was measured to determine best lubrication. 

#stearic acid #rice extract #ejection force #magnesium stearate #lubrication

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