Jan. 5, 2021

Impact of Incorporated Drugs on Material Properties of Amorphous Solid Dispersions

Read the paper from the Technical University Dortmund & Merck on the formulation development of amorphous solid dispersions (ASD). Three poorly soluble drugs were incorporated into copovidone via hot-melt extrusion and later characterised. The difference in brittleness, harness, compression and wettability were then tested. 

#mechanical characterization #nanoindentation #tablet compression #Hot-melt Extrusion #Wettability #Amorphous Solid Dispersion #Tablet disintegration