pharmaceutical-technology
July 25, 2022
On this article you will find how pharmaceutical companies can improve the efficiency of their entire product development and drug commercialisation process with the ever-rising costs of bringing a drug to market. A well-known source of bottlenecks, delays, and technical setbacks is process scale-up, where production moves from the laboratory to full-scale GMP manufacturing
MySTYL'One
July 22, 2022
The present works demonstrated from a study to predict capping on biconvex tablets from a wide range of products (18 formulations, 8 of which presenting capping), using the properties characterized on defect-free flat-faced tablets (tensile strength, solid fraction, elastic recovery, etc.). The study is available in the PAPERS section.
Find others papers here and learn about
The present works demonstrated from a study to predict capping on biconvex tablets from a wide range of products (18 formulations, 8 of which presenting capping), using the properties characterized on defect-free flat-faced tablets (tensile strength, solid fraction, elastic recovery, etc.). The study is available in the PAPERS section.
Find others papers here and learn about
pharmaceutical-technology
July 20, 2022
Tablets are by far the most widely used pharmaceutical dosage form, followed by capsules. Tablets are cost-effective, stable, and easy-to-administer. The main advantage is that compression allows for high speed manufacturing with a very high level of quality control. As such, tablets have been popular among pharmacists since the emergence of the tablet compression industry in the mid-20th century. Despite this long history, the industry is continually improving this dosage form to advance pat...
Tablets are by far the most widely used pharmaceutical dosage form, followed by capsules. Tablets are cost-effective, stable, and easy-to-administer. The main advantage is that compression allows for high speed manufacturing with a very high level of quality control. As such, tablets have been popular among pharmacists since the emergence of the tablet compression industry in the mid-20th century. Despite this long history, the industry is continually improving this dosage form to advance patient care. Meanwhile, the processes and equipment it uses to manufacture these products are also advancing.
MySTYL'One
June 20, 2022
The present work details the influence of the unloading step on capping using a compaction simulator. Full paper available in the PAPERS section.
Find others papers here and learn about
MySTYL'One
June 15, 2022
- The event is now over - Stay tuned for additional info soon
June 28th, 3 pm (Paris Time)
"Fundamental investigations on bilayer tablets - Effects of process parameters and geometry on interfacial strength"
#multilayer #tablet #interfacial adhesion #delamination #tablet geometry
MySTYL'One
Jan. 4, 2022
The purpose of this new study was to evaluate the processability and dissolution behavior of HPC GXF ((Klucel® GXF) and a recently introduced type of hot-melt extrudable HPMC (Affinisol®) in extended-release metformin hydrochloride formulations using twin-screw melt granulation. The powder blends were then granulated at different temperatures, then tableted. Rheological studies (steady steer rate viscosity and rotation rheometry) as well as dissolution studies were then performed. Full paper available in the PAPERS section.
#polymer #hydroxypropyl methylcellulose #melt extrusion #hydroxypropyl cellulose #rheology #twin screw melt granulation #binder #tablet
MySTYL'One
July 13, 2021
This new study from the University of Braunschweig explores the microstructure of tablets, analyzable thanks to X-ray microtomgraphy (XMT).
This helps to get a deeper understanding of their properties: mechanical strength, component distribution etc. XMT measurements are then compared with other methods used to characterize APIs. Access the paper HERE.
#pore size distribution #API homogeneity #Micro-cracks #tablet microstructure #tablet #X-ray microtomography
MEDELPHARM
May 3, 2021
There are numerous tablet defects: chipping, picking & sticking, cracking, lamination & capping to name a few.
Lamination & capping often occur during scale-up and are main issues in our industry. Capping is the partial or complete removal of the crown of a tablet from the main body, while lamination is the separation of a tablet into two or more distinct layers. However, those 2 phenomenon share similar causes...
www.manufacturingchemist.com
Nov. 24, 2020
One new interesting article we've discovered on manufacturingchemist.com, dealing with tablet design and its impact on patient acceptance.
What would be the benefits of a flat faced radius edge tablet design as compared to a flat faced bevel edge?
Full article is online here