This new study from the University of Braunschweig explores the microstructure of tablets, analyzable thanks to X-ray microtomgraphy (XMT). 

This helps to get a deeper understanding of their properties: mechanical strength, component distribution etc. XMT measurements are then compared with other methods used to characterize APIs. Access the paper HERE. 

There are numerous tablet defects: chipping, picking & sticking, cracking, lamination & capping to name a few.

Lamination & capping often occur during scale-up and are main issues in our industry. Capping is the partial or complete removal of the crown of a tablet from the main body, while lamination is the separation of a tablet into two or more distinct layers. However, those 2 phenomenon share similar causes...