MySTYL'One
Jan. 4, 2022
The purpose of this new study was to evaluate the processability and dissolution behavior of HPC GXF ((Klucel® GXF) and a recently introduced type of hot-melt extrudable HPMC (Affinisol®) in extended-release metformin hydrochloride formulations using twin-screw melt granulation. The powder blends were then granulated at different temperatures, then tableted. Rheological studies (steady steer rate viscosity and rotation rheometry) as well as dissolution studies were then performed. Full paper available in the PAPERS section.
#polymer #hydroxypropyl methylcellulose #melt extrusion #hydroxypropyl cellulose #rheology #twin screw melt granulation #binder #tablet
MySTYL'One
July 13, 2021
This new study from the University of Braunschweig explores the microstructure of tablets, analyzable thanks to X-ray microtomgraphy (XMT).
This helps to get a deeper understanding of their properties: mechanical strength, component distribution etc. XMT measurements are then compared with other methods used to characterize APIs. Access the paper HERE.
#pore size distribution #API homogeneity #Micro-cracks #tablet microstructure #tablet #X-ray microtomography
MEDELPHARM
May 3, 2021
There are numerous tablet defects: chipping, picking & sticking, cracking, lamination & capping to name a few.
Lamination & capping often occur during scale-up and are main issues in our industry. Capping is the partial or complete removal of the crown of a tablet from the main body, while lamination is the separation of a tablet into two or more distinct layers. However, those 2 phenomenon share similar causes...
www.manufacturingchemist.com
Nov. 24, 2020
One new interesting article we've discovered on manufacturingchemist.com, dealing with tablet design and its impact on patient acceptance.
What would be the benefits of a flat faced radius edge tablet design as compared to a flat faced bevel edge?
Full article is online here