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Keep up with the latest in the tableting community!


Showing posts tagged as : #tableting

Announcement

MySTYL'One

June 20, 2022

Impact of unloading kinematics on the occurrence of capping during the production of pharmaceutical tablets


The present work details the influence of the unloading step on capping using a compaction simulator. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Studying the impact of lubrication on tablet properties using STYL'One
  • The effect of spray drying on the compaction properties of hypromellose acetate succinate

#tableting #capping #compression #STYLOne #tablet #Defects

Announcement

MySTYL'One

May 24, 2022

Impact of Amylose-Amylopectin Ratio of Starches on the Mechanical Strength and Stability of Acetylsalicylic Acid Tablets


The present work details how moisture sorption properties of the starches with different amylose-amylopectin ratio impacted tablet properties including drug stability. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Compression Profiles of a Directly Compressible Starch using Compaction Simulation and High-Speed Tablet Press
  • Insights into the Moisture Scavenging Properties of Different Types of Starch in Tablets Containing a Moisture-Sensitive Drug
  • Starch-based...

The present work details how moisture sorption properties of the starches with different amylose-amylopectin ratio impacted tablet properties including drug stability. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Compression Profiles of a Directly Compressible Starch using Compaction Simulation and High-Speed Tablet Press
  • Insights into the Moisture Scavenging Properties of Different Types of Starch in Tablets Containing a Moisture-Sensitive Drug
  • Starch-based controlled release matrix tablets: Impact of the type of starch

#stability #tableting #moisture #Amylose #STYLOne #Amylopectin

Announcement

MySTYL'One

May 9, 2022

Prediction of the impact of lubrication on tablet compactibility


The present work details a model based on the Ryshkewitch-Duckworth equation that can estimate the compactibility profiles of lubricated formulations. Available model showing extended quantitative predictive accuracy for the influence of lubricant concentration on the mechanical strength of tablets. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Effect of binder type and lubrication method on the binder efficacy for direct compression
  • Evaluation of an externa...

The present work details a model based on the Ryshkewitch-Duckworth equation that can estimate the compactibility profiles of lubricated formulations. Available model showing extended quantitative predictive accuracy for the influence of lubricant concentration on the mechanical strength of tablets. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Effect of binder type and lubrication method on the binder efficacy for direct compression
  • Evaluation of an external lubrication system implemented in a compaction simulator
  • External lubrication system on the Styl’One Evolution

#tableting #Modeling #Multi-component compaction #Mechanical strength #STYLOne #lubrication

Announcement

MySTYL'One

April 21, 2022

Air entrapment during tablet compression–diagnosis, impact on tableting performance, and mitigation strategies


The present work compares the in-die elastic recovery profiles with and without precompression prior to the main compression of celecoxib powder. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Lamination of pharmaceutical tablets: Classification and influence of process parameters
  • Characterization and modeling of the viscoelasticity of pharmaceutical tablets
  • Unravelling capping issues using STYL'One dwell time or punch speed

#tableting #lamination #precompression #Air entrapment #Defects #celecoxib powder

Announcement

MySTYL'One

Jan. 18, 2022

Insight into tableted pellets by combining X-ray micro-computed tomography and experimental compaction

New study from the University of Montpellier developing a new approach to evaluate the deformation behavior of pellets when compressed.

Both data during tableting and compression models with XTM image analysis were combined.

Head to the Papers section and learn about

- mechanical behavior of pharmaceutical pellets when compressed
- deformation mechanism of ductile and brittle pharmaceutical pellets
- nondestructive X-ray micro-computed tomography for pellet deformation
- structure thickness an...

New study from the University of Montpellier developing a new approach to evaluate the deformation behavior of pellets when compressed.

Both data during tableting and compression models with XTM image analysis were combined.

Head to the Papers section and learn about

- mechanical behavior of pharmaceutical pellets when compressed
- deformation mechanism of ductile and brittle pharmaceutical pellets
- nondestructive X-ray micro-computed tomography for pellet deformation
- structure thickness and equivalent sphere diameters as morphometric parameters

#X-ray micro computed tomography #'experimental compaction' #tableting #pellet deformation

Feature article

Bruno Villa & Bruno Leclercq

April 3, 2021

Containment is a growing demand in R&D tableting equipment

The principle « better safe than sorry » is now widely applied in containment, mainly due to the following key factors: The number one factor is the stringent Labor Protection Law. An increase in safety rules and regulations for the workforce imposes strict control of operator exposure. Secondly with the increase of product efficiency and powders being more and more active, a higher level of protection has become necessary to ensure operation safety. Finally, with the advance of science we are more aware of risks created by active materials and more cautious about...

#R&D #API #safety #tableting #containment

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