Medelpharm
Jan. 18, 2023
MySTYL'One members exclusive!
can be challenging, due to the multiple competing technological aims, such as flow, compactability, lubrication and drug release. Tablets are complex and, whether due to ignorance or indeterminacy, uncertainty also makes it difficult to develop tablets robust enough to cope with scale-up and Production. Speed sensitivity of the compression mix can come as an unwelcome surprise to those who did not know that tablets have...
MySTYL'One members exclusive!
can be challenging, due to the multiple competing technological aims, such as flow, compactability, lubrication and drug release. Tablets are complex and, whether due to ignorance or indeterminacy, uncertainty also makes it difficult to develop tablets robust enough to cope with scale-up and Production. Speed sensitivity of the compression mix can come as an unwelcome surprise to those who did not know that tablets have speed limits! Speed sensitivity may also be called strain rate sensitivity. The penalty for exceeding the speed limit is capping, making tablet production impossible. During development capping/lamination is unacceptable for further progression.
#viscoelasticity #tablet development #scale-up #Quality by Design #capping
MySTYL'One
April 14, 2022
MySTYL'One user exclusive!
New bulletin available on using the extended dwell time compression profile on STYL'One Nano. Evaluate your powder viscoelasticity / viscoplasticity and study the mechanical behavior of your powders.
#bulletin #Dwell Time #viscoelasticity #viscoplasticity #compression profiling
MySTYL'One
April 14, 2022
MySTYL'One user exclusive!
New bulletin available on binding and tableting properties standard crystallized mannitol in β-polymorphic form for use with wet granulation. A comparison of different polymorphic forms.
#bulletin #Dwell Time #viscoelasticity #viscoplasticity #compression profiling
MySTYL'One
Jan. 9, 2022
The paper highlights an evaluation method to determine the effect of speed during tableting on the compression properties of pharmaceutical powders (APIs mixed with excipients).
Different tests were conducted to determine viscoelasticity, stress relaxation, followed by compaction on both STYL’One compaction simulator and a rotary press. Results show that the sensitivity of the out-of-die SRS was higher than that of in-die SRS.
Full results available in the paper, head to
the “Papers” section of...
The paper highlights an evaluation method to determine the effect of speed during tableting on the compression properties of pharmaceutical powders (APIs mixed with excipients).
Different tests were conducted to determine viscoelasticity, stress relaxation, followed by compaction on both STYL’One compaction simulator and a rotary press. Results show that the sensitivity of the out-of-die SRS was higher than that of in-die SRS.
Full results available in the paper, head to
the “Papers” section of MySTYL'One (members only).
#scale-up #viscoelasticity #'strain rate sensitivity' #'tableting speed' #'out-of-die' #'compression'