Enabling the direct compression of metformin hydrochloride through QESD crystallization

New paper Uni Düss



June 15, 2021

A new paper published by the university of Düsseldorf on the compression of Metformin Hydrochloride, a drug which had before not been directly compressed. However using a quasi-emulsion solvent-diffusion (QESD) crystallization technique allows for better flowability and reduce storage agglomeration, making direct compression possible after evaluating the tabletability of the material.

Full paper available here.  

#direct compression #'Metformin Hydrochloride' #'tablet capping' #precompression #'spherical crystallization' #STYLOne #flowability

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