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Discover scientific papers, case studies and tutorials dedicated to compression...

Tooling Terminology

All what you need to know about the size & format of Punches & Dies.

Some terminology such as D, B, 441, EU, TSM + a list of Punches & Dies compatible with STYL'One Evolution.


Compaction simulation / Industrial press correlation: Two case studies

In this article, Aline Moulin, PhD, Head of the New Product Introduction Department, and Lucile Kowalski, PhD, Pharmaceutical Development Project Manager, both of Skyepharma, examine two case studies comparing compaction simulation with industrial compression.

Internal play on STYL'One Evo

Why an internal play?

On rotary tablet presses with multilayer capabilities, just after the fill of the second blend, the first and second layers are pushed down by the upper punch.

On STYL’OneEvolution, the “internal play” on the lower punch aims at mimicking this very process.

When the upper punch is going down for compaction, it pushes the powder bed and the lower punch at the same time, the latter one being only retained by the punch break.

Acquisition plots

Compaction simulation as a QbD tool to develop complex oral solid dosage forms

This case study aims at showing that compaction simulation can be used as a QbD tool to develop complex oral solid dosage forms, at any step of development (prototyping, scale-up, manufacturing optimization) and in particular for complex oral solid dosage forms (tab in tab, multi-layer tablet)

Recent development and complex tablet formulation design for versatile applications

Mathieu Degomme, PharmD, Pharmaceutical Development Project Manager, and Aline Moulin, PhD, Pharmaceutical Development Director, both of Skyepharma, outline three case studies from recent early-stage development programmes to illustrate what kind of complex tablets can be developed to meet specific target dissolution profiles for versatile applications.

complex tablet
dissolution profile
press coating

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