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Discover scientific papers, case studies and tutorials dedicated to compression...

A QbD approach to shorten development time

Reducing “time to market” is the ultimate goal for every pharmaceutical lab. Being the fi rst on the market brings a competitive advantage for prescription, over-the-counter, or generic-drug manufacturers.

Applying quality-by-design (QbD) principles at the formulation phase can prevent tablet defects at an early stage and thereby drastically reduce time during the complex and troublesome phase of “scale-up.”


Energetics Approach

In physics, a force is said to do work if, when acting, there is a displacement of the point of application in the direction of the force.

This bulletin describes the different Work of Forces that are automatically calculated by STYL'One software. Those Works are named Plastic & Elastic energies in Analis. Somes authors use other terminologies, such as Net Energy, Work of Compression (Wc), Work of Decompression (Wd) and Work of Compression+Decompression (Wc/d).


Comparison of the Performance of Single Punch and Rotary Tablet Presses from Different Vendors

As tablets are the most common dosage form for drug delivery, many different rotary presses are available on the market in order to produce tablets with a high throughput. Single punch presses are used for pharmaceutical development or to simulate the compaction process using small material quantities. In this study, 5 different rotary presses and 4 single punch presses were utilized using 3 different model formulations. Tablet masses and tensile strengths were investigated as a function of compaction force and process time.

force-time profiles
rotary tablet presses
single punch tablet presses
tensile strength

Tooling Terminology

All what you need to know about the size & format of Punches & Dies.

Some terminology such as D, B, 441, EU, TSM + a list of Punches & Dies compatible with STYL'One Evolution.


Compaction simulation / Industrial press correlation: Two case studies

In this article, Aline Moulin, PhD, Head of the New Product Introduction Department, and Lucile Kowalski, PhD, Pharmaceutical Development Project Manager, both of Skyepharma, examine two case studies comparing compaction simulation with industrial compression.

Internal play on STYL'One Evo

Why an internal play?

On rotary tablet presses with multilayer capabilities, just after the fill of the second blend, the first and second layers are pushed down by the upper punch.

On STYL’OneEvolution, the “internal play” on the lower punch aims at mimicking this very process.

When the upper punch is going down for compaction, it pushes the powder bed and the lower punch at the same time, the latter one being only retained by the punch break.

Acquisition plots

Compaction simulation as a QbD tool to develop complex oral solid dosage forms

This case study aims at showing that compaction simulation can be used as a QbD tool to develop complex oral solid dosage forms, at any step of development (prototyping, scale-up, manufacturing optimization) and in particular for complex oral solid dosage forms (tab in tab, multi-layer tablet)


Recent development and complex tablet formulation design for versatile applications

Mathieu Degomme, PharmD, Pharmaceutical Development Project Manager, and Aline Moulin, PhD, Pharmaceutical Development Director, both of Skyepharma, outline three case studies from recent early-stage development programmes to illustrate what kind of complex tablets can be developed to meet specific target dissolution profiles for versatile applications.

complex tablet
dissolution profile
press coating

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